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Yıl:2015; Cilt: 52; Sayı: 2>> Özet
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Nöropsikiyatri Arşivi; 2015;52(2):145-150
Bakımevinde Yaşayan ve Psikotik Bozukluğu Olan Bireylerde Antipsikotik İlaç Kullanma Örüntüsü
EE Ersan, M Yıldız
Numune Hastanesi, Sivas
Amaç: Bakımevlerinde kalan ve psikotik bozukluğu olan hastalardaki antipsikotik ilaç kullanma örüntüsünü ve ilişkili etmenleri incelemek bu çalışmanın amacıdır. Yöntem: Bakımevlerinde kalan, psikiyatri polikliniğinde ayaktan izlenen ve DSM-IV’e göre psikotik bozukluk tanısı alan hastaların ilaç kullanma örüntüsü incelendi. En az bir aydır çoklu antipsikotik ilaç (ÇAPİ) kullanan hastalar klinik ve nüfus özellikleri açısından tekli antipsikotik ilaç (TAPİ) kullanan hastalarla karşılaştırıldı. Bulgular: ÇAPİ kullanma oranı %62 (ikili: %34, ikiden fazla: %28) idi. İkili APİ kullanımında en çok tercih edilen birliktelik olanzapin-ketiapin (%13) idi. İkili kullanımda 1 ve 2. kuşak APİ birliktelik oranı %50, 2. kuşak APİ’lerin birliktelik oranı %44, birinci kuşak APİ’ların birliktelik oranı ise %4 idi. Klozapin kullanım oranı %3 idi. ÇAPİ kullanımı tanısı şizofreni ve şizoaffektif bozukluk olan hastalarda, genç hastalarda, intihar girişimi olanlarda, hastane yatışı fazla olanlarda ve klinik düzeyi daha şiddetli olanlarda daha fazla saptandı. ÇAPİ kullanımı antikolinerjik ilaç gereksinimi ile de ilişkili idi. Sonuç: Bakımevinde yaşayan psikotik bozukluk hastalarında ikiden fazla APİ birlikte kullanımı yüksek oranda (%28) olmasına rağmen klozapine çok az yer verilmiş olması tedavi kılavuzlarının önerilerine pek uyulmadığını göstermektedir. Ruh hekimliği uygulamalarında akılcı APİ kullanımına yönelik eğitime daha fazla gereksinim var gibi durmaktadır.
Antipsychotic Use Pattern in People with Psychotic Disorder Living in Board and Care Facilities
Introduction: The aim of this survey is to determine the pattern of antipsychotic drug use in patients with psychotic disorders, living in board and care facilities and to investigate the related factors. Methods: We evaluated the antipsychotic drug use pattern in outpatients with psychotic disorders according to DSM-IV, living in board and care facilities. Patients using polypharmacy at least one month were compared with patients using monotherapy in terms of clinical and demographic characteristics. Results: Antipsychotic polypharmacy (with two: 34%, with more than two: 28%) was identified in 62% of the patients. The most frequently prescribed combination was olanzapine+quetiapine (13%), the rate of first and second generation combination was 50%, the rate of second generation antipsychotic combination was 44%, and the rate of first generation anytipsychotic combination was 4% in the two antipsychotic drug combination group. The rate of clozapine use was 3%. Use of polypharmacy was associated with the diagnosis of schizophrenia and schizoaffective disorder, young age, suicidal behavior, multiple hospitalizations, clinical severity, and the need of anticholinergic drug. Conclusion: The ratio of using more than two antipsychotic drug combination is high (28%) in psychotic patients living in board and care, and rate of clozapine use is low, which shows that clinical practice is inconsistent with the treatment guidelines recommendations. It appears that further education to rationale antipsychotic drug use in psychiatric practices is required.

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