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Yıl:2015; Cilt: 52; Sayı: 2>> Özet
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Nöropsikiyatri Arşivi; 2015;52(2):194-197
İlk Dönem Manide Spektral Güç Yoğunluğu: Ardışık İyilik Dönemi ile Karşılaştırmalı Bir Çalışma
S Güven, S Kesebir, RM Demirer, M Bilici
Sandıklı Devlet Hastanesi, Kütahya
Amaç: Bu çalışmada amacımız, ilk dönem mani ve ardışık iyilik döneminde elektroensefalografi (EEG) spektral güç yoğunluklarını (PSD) araştırmak ve birbirinden farklılaşıp farklılaşmadığını değerlendirmektir. Yöntem: Bu çalışmada, son bir yıl içerisinde hastanemize başvurmuş, Ruhsal Bozuklukların Tanısal ve İstatistiksel Elkitabı-IV’e (DSM-IV) göre iki uçlu bozukluk, manik dönem tanılı, ilk dönem 69 olgu ardışık olarak değerlendirilmiştir. Dışlama ölçütleri, önceki depresif epizotu olmak, çekim öncesi EEG’yi etkileyebilecek ilaç kullanmış olmak, özellikle epilepsi olmak üzere önceki nörolojik hastalık, kafa travması ve/ya da bilinç kaybıdır. EEG çekimleri, digital EEG cihazı ile 16 kanal olarak yapılmıştır. Yirmi üç adet yüzey elektrodu uluslararası 10-20 sistemine göre yerleştirilmiştir. Bu çalışmada, EEG işaretinin spektral güç yoğunluğu (dbuV/Hz), EEG dalgalarının tanımlanan frekans aralığında birim frekans başına taşıdığı güç hakkında bilgi vermektedir. Bulgular: Sağ FP2P4 ve sol F7T3 elektrotlarında saptanan tepe güç değeri manik dönemde, iyilik döneminde olduğundan yüksek bulunmuştur (p=0,018 ve 0,025). İyilik döneminde, manik dönemde iken psikotik bulgusu olan olgularda, F4C4 tepe güç değeri, manik dönemde iken psikotik bulgusu olmayan olgulardan düşük bulunmuştur (p=0,027). YMRS puanları ile tepe güç değerleri arasında bir bağıntı yoktur. Sonuç: Duygudurum döneminin elektrofizyolojik izdüşümü, hastalığın başlangıcından itibaren mevcuttur ve mani ve iyilik dönemleri arasında birbirinden farklıdır. İyilik döneminde SPD’nin tepe güç değerleri, manik dönemde iken psikotik bulgusu olan olguları, psikotik bulgusu olmayan olgulardan ayırdetmektedir.
Electroencephalography Spectral Power Density in First-Episode Mania: A Comparative Study with Subsequent Remission Period
Introduction: Our aim in this study was to investigate spectral power density (PSD) in first-episode mania and subsequent remission period and to evaluate their difference. Methods: Sixty-nine consecutive cases referring to our hospital within the previous 1 year, who were evaluated as bipolar disorder manic episode according to The Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) at the first episode and had the informed consent form signed by first degree relatives, were included in this study. Exclusion criteria included having previous depressive episode, using drugs which could influence electroencephalographic activity before electroencephalography (EEG), and having previous neurological disease, particularly epilepsy, head trauma, and/or loss of consciousness. EEG records were obtained using a digital device in 16 channels; 23 surface electrodes were placed according to the International 10–20 system. Spectral power density (dbµV/Hz) of EEG signal provided information on the power carried out by EEG waves in defined frequancy range per unit frequency in the present study. Results: A peak power value detected on the right with FP2P4 and on the left with F7T3 electrodes were found to be higher in the manic episode than in the remission period (p=0.018 and 0.025). In the remission period, in cases with psychotic symptoms during the manic period, F4C4 peak power value was found to be lower than that in cases with no psychotic findings during the manic period (p=0.027). There was no relation was found between YMRS scores and peak power scores. Conclusion: Electrophysiological corollary of mood episode is present from the onset of the disease, and it differs between the manic and remission periods of bipolar disorder. In the remission period, peak power values of PSD distinguish cases with psychotic findings from cases without psychotic findings when they were manic.

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