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Yıl:1998; Cilt: 8; Sayı: 1>> Özet
TAM METİN
Klinik Psikofarmakoloji Bülteni; 1998;8(1):43-46
Normal basınçlı hidrosefali üzerinde gelişen nöroleptik malign sendromu
A Sır, M Özkan, E Özdemir, Ü Özkan, B Bebek
Dicle Üniversitesi, Diyarbakır
Nöroleptik malign sendromun patogenezi henüz tartışmalıdır ve santral sinir sisteminde özgül yapısal bir anormallik tanımlanmamıştır. Normal basınçlı hidrosefalinin eşlik ettiği bir nöroleptik malign sendrom olgusu sunulmuş ve nigrostriatal patolojinin nöroleptik malign sendrom gelişimine yatkınlık sağlayıp sağlamadığı tartışılmıştır. Nöroleptik malign sendrom etyopatogenezi ile ilgili olarak dopamin hipotezi de ele alınmıştır.

Neuroleptic malignant syndrome developed on normal pressure hydrocephalus
The pathogenesis of the neuroleptic malignant syndrome is still controversial and no specific morphological abnormalities in the central nervous system have been described. A case of neuroleptic malignant syndrome associated with normal pressure hydrocephalus is being reported. We suggest that, nigrostriatal pathology cause vulnerability to neuroleptic malignant syndrome. We discussed the dopamine dysfunction hypothesis related to the etyopathogenesis of neuroleptic malignant syndrome.

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