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Yıl:2020; Cilt: 57; Sayı: 1>> Özet
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Nöropsikiyatri Arşivi; 2020;57(1):71-77
Laboratuvardan Kliniğe Bir Konsept Olarak Empati: Translasyonel Bakış
N Uysal , UM Çamsarı , M Ateş , S Kandiş , A Karakılıç , GB Çamsarı
Dokuz Eylül Üniversitesi, İzmir
Empati kavramı henüz üzerinde bilimsel bir konsensusa varılamamış çok boyutlu bir paradigmadır. Bu yazıda, empati konusunu çalışanlar dahil ama bunlarla sınırlı olmamak üzere, davranışsal sinirbilim deneyleri sırasında verileri değerlendirme sorunlarını gözden geçirdik. Deney protokolleri empati ve ilgili süreçleri birçok düzeyde etkileyebilir ve etkileyebilir. Araştırmacıların empati üzerine davranışsal araştırmalar için başarılı bir çeviri yöntemi geliştirmelerine yardımcı olmak için çeşitli noktaları tartıştık. Empatinin yaygın olarak kabul edilmiş bir deneysel modeli olmamasına rağmen, mevcut kemirgen modelleri nöropsikiyatrik yönden tatmin edici açıklamalar sunmaktadır ve güncel literatür empatinin bu derlemede etraflıca işleneceği üzere birçok parametreden etkilendiğini ortaya koymaktadır. Bu makalede, gelecekteki empati araştırmalarının temel ve klinik bilimlerden farklı bakış açılarına sahip araştırıcıların katkısıyla yaratılmış tutarlı translasyonel modellere bağlı olduğunu ve ana akım deneysel modellerde tamamen yok sayılmasına karşın empatinin deneysel çalışmalarda sonuçları etkileyebilecek bağımsız bir değişken olabileceği olasılığını irdeledik.
Empathy as a Concept from Bench to Bedside: A Translational Challenge
Empathy is a multidimensional paradigm, and there currently is a lack of scientific consensus in its definition. In this paper, we review the possibility of compromising data during behavioral neuroscience experiments, including but not limited to those who study empathy. The experimental protocols can affect, and be affected by, empathy and related processes at multiple levels. We discuss several points to help researchers develop a successful translational pathway for behavioral research on empathy. Despite varying in their focus with no widely accepted model, current rodent models on empathy have provided sound translational explanations for many neuropsychiatric proof-ofconcepts to date. Research has shown that empathy can be influenced by many parameters, some of which are to be reviewed in this paper. We emphasize the future importance of consistency in modeling proof of concept; efforts to create a multidisciplinary group which would include both bench scientists and clinicians with expertise in neuropsychiatry, and the consideration of empathy as an independent variable in animal behavioral experimental designs which is not the mainstream practice at present.

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