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Yıl:2022; Cilt: 59; Sayı: 1>> Özet
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Nöropsikiyatri Arşivi; 2022;59(1):38-43
Antisosyal Kişilik Bozukluğu Olan Hastalarda Periferik İnflamatuar Parametreler
G Taşcı, Ş Kaya, S Korkmaz, M Atmaca
Elazığ Fethi Sekin Şehir Hastanesi, Elazığ
Amaç: Bu çalışmada Antisosyal Kişilik Bozukluğu (AKB) hastalarında periferik inflamatuar parametrelerden; lökosit hücre düzeyleri, kırmızı kan hücresi dağılım genişliği (RDW), ortalama platelet hacmi (MPV), nötrofil lenfosit oranı (NLO), platelet lenfosit oranı (PLO), monosit lenfosit oranı (MLO), bazofil lenfosit oranı (BLO) değerlerinin sağlıklı kontroller ile karşılaştırılarak incelenmesi amaçlanmıştır. Yöntem: Çalışmamıza AKB tanılı 48 hasta ve hastalarla eşleştirilmiş sağlıklı kontrol grubunu oluşturan 52 kişi alındı. Katılımcılardan aç karnına ve günün aynı saatine denk gelecek zamanlarda venöz kan örneği alındı. Tüm katılımcılara; sosyodemografik veri formu, Beck Depresyon Ölçeği (BDÖ), Beck Anksiyete Ölçeği (BAÖ), Barratt Dürtüsellik Ölçeği (BIS-11), Buss-Durkee Saldırganlık Ölçeği (BDSÖ) uygulandı. Sonuçlar: Hastalarda RDW ve bazofil hücre düzeyleri, kontrollerden anlamlı olarak yüksek idi (sırasıyla p=0,005, p=0,038). BLO, alkol kullanımı olan katılımcılarda kullanmayanlara göre anlamlı olarak yüksek bulundu (p=0,016). Diğer laboratuvar parametreleri ve MPV, NLO, PLO, MLO değerlerinde hasta ve kontrol grubu arasında anlamlı bir fark saptanmadı. Hastalarda BDÖ, BAÖ, BIS-11, motor dürtüsellik alt boyutu ve BDSÖ, fiziksel saldırganlık, öfke duyma, düşmanlık duyma, sözel saldırganlık alt boyutlarının puanları ve ölçeğin genel toplamında saldırganlık düzeyleri kontrollerden anlamlı olarak yüksek bulundu (sırasıyla p
Peripheral Inflammatory Parameters in Patients with Antisocial Personality Disorder
Introduction: The aim of the study was to examine the peripheral inflammatory parameters in patients with Antisocial Personality Disorder (APD) including white blood cell levels, red cell distribution width (RDW), mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), basophil-to-lymphocyte ratio (BLR) by comparing with those of healthy controls. Methods: 48 patients diagnosed with APD and a matched healthy control group of 52 individuals were included in our study. Venous blood samples were taken from the participants in the fasting state and at approximately the same time of the day. Socio-demographic data sheet, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Barratt Impulsiveness Scale (BIS-11), Buss-Durkee Hostility Inventory (BDHI) were applied to all of the participants. Results: RDW and basophil cell levels were found significantly higher in the patients than the controls (p=0.005, p=0.038 respectively). BLR was found significantly higher in the participants with alcohol use than those without alcohol use (p=0.016). No significant difference in other laboratory parameters was found between the patient group and the control group. Scores of BDI, BAI, BIS-11, motor impulsivity subscale and physical aggression, anger, hostility and verbal aggression subscales of BDHI, and the total score of BDHI were significantly higher in patients than controls (p

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