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Yıl:2006; Cilt: 16; Sayı: 4>> Özet
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Klinik Psikofarmakoloji Bülteni; 2006;16(4):233-238
Psikotik bozukluğu olan ve antipsikotik ilaç kullanan hastalarda obezite sıklığı ve bir yılın sonunda kilo değişimi
C Cerit, M Yıldız, S Candan
Kocaeli Ü. Tıp Fak. Psikiyatri ABD, İstanbul
Amaç: Türkiye’de psikotik bozukluğu olan ve antipsikotik ilaç tedavisi gören hastalarda obezite sıklığını bildiren bir çalışma bulunmamaktadı r. Bu çalışmada psikotik bozukluğu olan ve antipsikotik ilaç kullanan hastalarda obezite sıklığının saptanması ve bir yılın sonunda hastalarda kilo değişimi olup olmadığının araştırılması amaçlanmıştır.

Yöntem: Psikotik bozukluk tanısıyla takip edilen ve antipsikotik ilaç tedavisi alan poliklinik hastaları çalışmaya alındı. Başlangıçta hastaları n nüfus, klinik verileri ve beden kitle göstergeleri (BKG) kaydedildi. Bir yıl sonra hastaların BKG’ leri tekrar değerlendirildi.

Bulgular: Çalışmaya alınan 324 hastanın başlangıçtaki BKG ortalaması 27.43±5.11 kg/m2, bu hastalardaki obezite sıklığı %25.4 olarak bulunmuştur. Kadınların BKG ortalaması (28.66±5.52) erkeklerden (26.57±4.62) daha yüksek bulunmuştur. Bir yıllık takibi tamamlanan 109 hastanın başlangıç ve 12. aydaki BKG ortalamaları (sırasıyla 27.86±5.12, 27.92±5.10) arasında istatistiksel olarak anlamlı bir fark gözlenmemiştir. Benzer şekilde alt grup olarak kadınların, erkeklerin, şizofreni tanısı alanların, diğer psikotik bozukluğu olanların ve farklı antipsikotikleri kullananların da başlangıç ve 12. aydaki BKG ortalamaları arasında anlamlı bir fark gözlenmemiştir.

Tartışma: Bu çalışmada psikotik bozukluğu olan hastalarda obezite sıklığı, Türkiye’de sağlıklı erişkin nüfustaki obezite sıklığından daha yüksek görünmektedir. Kadınlar erkeklerden daha fazla risk altındadı rlar. Bir yılın sonunda kilo alımında önemli ölçüde bir değişiklik gözlenmemiş olsa da bu hastaların önemli bir bölümü kilolu ya da obezdir. Bu nedenle tedaviye kilo yönetimi ile ilgili programların eklenmesi yararlı olabilir.
The prevalence of obesity and weight gain among thepatients with psychotic disorder who use antipsychotic medication, one [year] follow-up
Objective: There is no study about the prevalence of obesity inpatients with psychotic disorder who use antipsychotic medication inTurkey. The aim of this study was to determine the prevalence ofobesity in patients with psychotic disorder who use antipsychoticmedication and whether weight gain occurs or not underantipsychotic medication for one [year] in these patients.Methods: Outpatients with psychotic disorder who use antipsychoticmedication included in this study. Demographic and clinical variablesand Body Mass Index (BMI) values were recorded at the beginning.BMI values were assessed again one [year] later. Results: Of the 324 patients, the mean BMI value was 27.43±5.11kg/m2, the obesity prevalence was 25.4%.The mean BMI value offemales (28.66±5.52) was higher than males (26.57±4.62). There wasno significant difference between the mean BMI values of the 109patients at the beginning and at the 12.th [month] (respectively27.86±5.12, 27.92±5.10). Similarly there were no significantdifferences between the mean BMI values of such subgroubs likefemales, males, patients with schizophrenia, patients with otherpsychotic disorders and different antipsychotic users at the beginning and at the 12.th [month].Conclusion: In this study, the prevalence of obesity in patients withpsychotic disorder seems to be higher when compared with thehealty adult population in Turkey. Females are at much risk thanmales. Even there was no change on weight gain at the end of one [year], most of these patients were overweight or obese. For thisreason, adding the weight manegement programs to the treatmentwould be useful with these patients.

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