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Yıl:2008; Cilt: 18; Sayı: 2>> Özet
TAM METİN
Klinik Psikofarmakoloji Bülteni; 2008;18(2):92-98
İnme Hastalarında Lezyon Lokalizasyonu ve Depresyon İlişkisi
E Koçer, C Bilge, S Çağrıcı, H Tutkan, A Koçer
Düzce Tıp Fak. Psikiyatri AD, Düzce-Türkiye
Amaç: Bu çalışmanın amacı inme hastalarında lezyon lokalizasyonu ile depresyon arasındaki ilişkiyi araştırmaktır.
Yöntem: Daha önce hiç inme öyküsü olmayan ve çalışmaya alınma kriterlerini karşılayan 40 hasta 6 ay süreyle prospektif olarak değerlendirildi. Depresyon varlığı bir uzman psikiyatrist tarafından DSM-IV tanı kriterleri ve Hamilton depresyon skalası kullanılarak değerlendirildi. Kraniyal görüntülemelerle elde edilen lezyon lokalizasyonuna ait veriler standart bir metodoloji kullanılarak ön, orta veya arka / sağ veya sol hemisfer yerleşimli lezyonlar şeklinde sınıflandırıldı. Takip sürecinde depresyon gelişen olgular ile depresyon gelişmeyen olgular arasındaki lezyon farklılıkları araştırıldı.
Bulgular: Çalışma grubumuz 13’ü kadın (%32.5) ve 27’si erkek (%67.5) 40 hastadan oluşmaktaydı. Depresyon ile hemisfer farklılığı arasında farklılık saptanmamasına karşın, ön taraf tutulumu ile depresyon arasında istatistiksel olarak anlamlı fark olduğu tespit edildi.
Sonuç: Daha önce birçok yapısal görüntüleme çalışmalarının aktardığı, nöropsikolojik değerlendirmeler ve fonksiyonel çalışmalar depresyon
ile sol taraf ve ön bölge lezyonları arasında bir ilişkiyi gösteren verilere
benzer olarak bu çalışmada da depresyon ile ön bölge tutulumu
arasında bir ilişki bulunabileceği saptanmıştır.

The relationship between depression and lesion localization in first-ever stroke patients
Objective: There is a need for more systematical and wide-spread studies because of the methodological problems in scientific studies discussing the relationship between depression and localization.
Method: Forty patients with first stroke and meeting the inclusion criteria were examined prospectively during 6 [month] study period. The diagnosis of depression was made by using DSM-IV diagnostic tool and the patients were followed by using Hamilton Depression Scale by a specialist on psychiatry. The findings got from the cranial imaging were evaluated and classified as lesions located in anterior, posterior or medial part / in the left or right hemisphere by using a standard method. The differences of lesions between the patients who developed the depression and the patients without depression were evaluated during follow-up period.
Results: The study population consisted of 40 patients - 13 women (32.5%) and 27 men (67.5%). The relationship between depression and lesionlocalization whether right or left hemisphere was not
significant , but the relationship between depression and anteriorly
located lesions was statistically significant.
Conclusion: Additional to previous structural imaging studies,
neuropsychological examinations and functional studies reporting a
relation between development of depression and lesions located on
the left side and anterior part, our results show that there could be a
relationship between depression and anterior lesions in the first ever
stroke patients.

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