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Yıl:2009; Cilt: 46; Sayı: 3>> Özet
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Nöropsikiyatri Arşivi; 2009;46(3):121-124
Karbonmonoksit Zehirlenmesine Bağlı Bir Geç Ensefalopati Olgusunda Nöropsikiyatrik Bulgular
AE Sargın, H Dönmez, S Örsel, TK Yoldaş
Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Ankara
Karbon monoksit (CO) zehirlenmesi ölümcül seyredebilen ve ülkemizde özellikle kış aylarında kapalı ortamlarda yakılan kömür sobalarına bağlı olarak sık görülen bir halk sağlığı sorunudur. Ülkemizde zehirlenme nedeniyle ölümlerin yarısından fazlasında neden karbon monoksit zehirlenmesidir. Özellikle akut zehirlenmeyi takiben sessiz dönemden sonra ortaya çıkan geç anoksik ensefalopati (GAE) olgularında yanlış tanı alma olasılığı artmaktadır GAE'nin semptom üçlüsü mental durumda bozulma, idrar ve/veya gaita inkontinansı ve yürüyüş bozukluğudur. GAE'de ki psikiyatrik görünüm; demans, amnestik sendromlar, organik affektif bozukluklar, kişilik bozuklukları ve psikozu da içeren çok farklı klinik bulgularla ortaya çıkmaktadır. Bu yazıda 35 yaşında, daha önce psikiyatrik ya da nörolojik bir hastalığı olmayan ancak 33 gün önce CO zehirlenmesi geçiren ve hiperbarik oksijen (HBO) tedavisi sonrasında tam düzelme halinde taburcu edildiği öğrenilen ve 15 günlük sessiz bir dönemi takiben psikiyatri polikliniğine sinirlilik, unutkanlık şikayetleri nedeniyle başvuran bir erkek hasta sunulmuştur. Bu hastadaki nöropsikiyatrik bulguların ayırıcı tanısı, kraniyal manyetik rezonans görüntüleme (MRG) bulguları ile birlikte tartışılmıştır.
Neuropsychiatric Findings in a Delayed Encephalopathy Due to Carbon Monoxide Intoxication
Carbon monoxide (CO) intoxication can be a deadly condition and is a very common public health problem in Turkey due to the use of coal stoves during the winter [month]s in homes. Carbon monoxide intoxication accounts for more than half of the deaths due to intoxications in Turkey. It is very likely to misdiagnose the cases of delayed anoxic encephalopathy (DAE) which are seen after the latent period following the acute intoxication. In delayed anoxic encephalopathy, following complete recovery and after a latent period, neurologic and/or psychiatric symptoms appear again. The symptom triad of DAE is mental deterioration, urinary and/or gaita incontinence and gait disturbances. The

psychiatric appearance in DAE can be seen in a variety of very different findings including dementia, amnestic syndromes, organic affective disorders, personality disorders and psychosis. In this case report, we present a 35- [year]-old man, who was admitted to the hospital because of irritability and loose mind. The patient did not have any previous psychiatric or neurologic disorder, but he had CO intoxication 33 days before the admission and was discharged from the hospital following a hyperbaric oxygen treatment with a complete recovery. After a 15-day latency period he was admitted to the hospital because of the mentioned symptoms. The differential diagnosis of the rich neuropsychiatric findings together with cranial magnetic resonance imaging findings (MRI) are discussed in this patient.

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